Search results for "DNA Alteration"

showing 3 items of 3 documents

Genotoxicity of the fungicide dichlofluanid in seven assays

1991

Seven different endpoints for detection of genotoxicity have been used to demonstrate the DNA-altering properties of Dichlofluanid, a fungicide commonly used in viticulture pest control. Each endpoint (DNA synthesis inhibition test, alkaline viscosimetry, umu-test, alkaline filter elution, FADU-test, 32P-postlabeling, and electron microscopy) shows clear evidence of genotoxicity. These data indicate that application of the fungicide dichlofluanid may be mutagenic and/or carcinogenic for exposed humans.

DNA ReplicationSalmonella typhimuriumDNA AlterationEpidemiologyHealth Toxicology and MutagenesisDichlofluanidmedicine.disease_causeCell LineMicechemistry.chemical_compoundmedicineAnimalsHumansBioassayGenetics (clinical)CaptanCarcinogenAniline CompoundsMutagenicity TestsFishesDNAPesticideFungicides IndustrialFungicideBiochemistrychemistryGenotoxicityDNA DamageHeLa CellsMutagensEnvironmental and Molecular Mutagenesis
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First Nationwide Molecular Screening Program in Spain for Patients With Advanced Breast Cancer: Results From the AGATA SOLTI-1301 Study

2021

Anàlisi de seqüències d'ADN; Subtipus PAM50; Genètica molecular Análisis de secuencias de ADN; Subtipo PAM50; Genética molecular DNA sequence analyses; PAM50 subtype; Molecular genetic Background: The SOLTI-1301 AGATA study aimed to assess the feasibility of a multi-institutional molecular screening program to better characterize the genomic landscape of advanced breast cancer (ABC) and to facilitate patient access to matched-targeted therapies in Spain. Methods: DNA sequencing of 74 cancer-related genes was performed using FFPE tumor samples in three different laboratories with three different gene panels. A multidisciplinary advisory board prospectively recommended potential targeted trea…

OncologyCancer ResearchDNA Alterationmedicine.medical_specialtymolecular targeted therapyAdvanced breast:Neoplasms::Neoplasms by Site::Breast Neoplasms [DISEASES]Cancer therapy:terapéutica::farmacoterapia::terapia molecular selectiva [TÉCNICAS Y EQUIPOS ANALÍTICOS DIAGNÓSTICOS Y TERAPÉUTICOS]:Therapeutics::Drug Therapy::Molecular Targeted Therapy [ANALYTICAL DIAGNOSTIC AND THERAPEUTIC TECHNIQUES AND EQUIPMENT]Breast cancerbreast cancerInternal medicineGene panelmolecular geneticmedicineDNA sequence analysesRC254-282Original ResearchFarmacologia molecular:neoplasias::neoplasias por localización::neoplasias de la mama [ENFERMEDADES]:Natural Science Disciplines::Biological Science Disciplines::Biology::Computational Biology::Genomics [DISCIPLINES AND OCCUPATIONS]Molecular screeningbusiness.industryCancerNeoplasms. Tumors. Oncology. Including cancer and carcinogensmedicine.diseaseOncologyMama - Càncer - Tractament:disciplinas de las ciencias naturales::disciplinas de las ciencias biológicas::biología::biología computacional::genómica [DISCIPLINAS Y OCUPACIONES]Mama - Càncer - Aspectes molecularsPAM50 subtypebusiness
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Photosensitization and phototherapy with furocoumarins: A quantum-chemical study

2008

Abstract The effect of electromagnetic radiation on biological objects extends from heating to complex photochemistry, and includes DNA alteration, that properly modified in damaged cells may entail beneficial effects. In this regard, psoralen + UV-A (PUVA) therapy, in which furocoumarins, psoralen-like chromophores, are used as photosensitizers and photoreactants with DNA bases, is one of the most promising strategies against a plethora of diseases. Understanding the underlying photochemical mechanisms is crucial to design effective drugs without undesired side effects. We have undertaken a quantum-mechanical study on the photophysics and photochemistry of furocoumarins, analyzing firstly …

Quantum chemicalFurocoumarinsDNA AlterationIntersystem crossingChemistryExcited stateGeneral Physics and AstronomySinglet statePhysical and Theoretical ChemistryChromophoreTriplet statePhotochemistryChemical Physics
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